“We are all holding.” —Terrance Mckenna.
It is not about regulated toxic drugs but enjoyable drugs. You can buy drugs such as cyanide, DDT, herbicides, and pesticides that will kill you in low doses. The safest drugs that we know of are psilocybin, DMT, LSD, which is banned throughout most countries. Journalists were the most responsible for making them illegal in the ’60s. They put out many articles revolving around the falsified information about how psychedelics change people. For example, they would say things like it makes people vicious serial killing psychopaths. We will look at some of the fantastic benefits of the most complicated chemical used in pharmacology today. That plant medicine, of course, is called Ibogaine. It is found in Africa, extracted from the iboga plant, used for millennia in that beautiful continent. Ibogaine is broken down in the liver after digests into the gut wall, converting into noribogaine (12-hydroxyibogamine).
Ibogaine and noribogaine share similar properties, but noribogaine stays in the body much longer. Ibogaine and noribogaine easily cross the blood-brain barrier and higher brain tissue concentrations than the bloodstream. It has one of the most complex pharmacology’s known to biochemists. There is absolutely nothing it does not do. You have the alpha three beta four nicotinic acetylcholine, the target for Wellbutrin, responsible for the smoking sensation and anti-addictive effects. These receptors make up the pathway to the brains’ reward centre. Meaning these receptors are involved in the mechanism of addiction. One study of 27 opioid addicts withdrawing from methadone, an opioid substitution therapy, found that noribogaine was well tolerated it moderately improved opioid withdrawal symptoms.
Furthermore, numerous animal models (such as rats and mice) have found that ibogaine exhibits anti-addictive properties against cocaine, morphine, amphetamine, alcohol, and nicotine. Ibogaine successfully blocks nicotinic acetylcholine receptors, keeping up a healthy acetylcholine level for a more extended period. It also affects the MNDA receptors, similar to a ketamine effect.
Ibogaine can block NMDA receptors, which account for its hallucinogenic effects.
Ibogaine has a classical psychedelic effect with the 5HT2A receptors. It is a dopamine reuptake inhibitor.
Ibogaine has similar effects on dopamine transporters giving the user heighten levels of dopamine. The dopamine level in addicted people is transformed due to the excessive use of abused drugs, such as cocaine. Synthizesed ibogaine hydrochloride was once sold under the name Lambarene in France (1939-1970) as an antidepressant and stimulator of mental state.
Ibogaine can reset the brain’s dopamine levels to pre-addiction levels.
Ibogaine is a serotonin reuptake inhibitor.
Ibogaine releases this protein GDNF, one of the most necessary treatments in Parkinson’s disease — it is one of the only things proven to regrow dopaminergic neurons.
Ibogaine has antimicrobial properties. Studies done with mice showed that iboga alkaloids reduced the number of deaths caused by Candida albicans infections.
Ibogaine creates enzymes called lipases that are handled by Candida albicans to attack human cells. When you combined it with a commonly used antibiotic, it prevents fungus growth.
Ibogaine is also found to have antimycobacterial activity, as shown by reducing several pathogenic microorganisms’ bacterial cultures.
The Iboga Plant
Some studies conducted on human blood cells showed that Ibogaine interrupts retroviruses’ replication (such as HIV–1) and blocks the infection process.
Ibogaine is also used in Africa to cure HPV.
Ibogaine acts as an antioxidant, and it increases the activity of antioxidant enzymes (SOD1) in human red blood cells. In observational trials, Ibogaine dramatically improved symptoms of anxiety, depression, and obsessive-compulsive disorder for an extended period after ibogaine treatments.
Synthetic iboga alkaloids have now been proven as a treatment for obesity in rats. Chronic use of this substance in rats prevented increases in weight gain, decreased fat deposition, and reduced sugar consumption.
Early studies suggest that Ibogaine has anti-cancer properties. In the lab, Ibogaine reversed multidrug resistance in human cancer cells.
“I am not here to build a business; I am not here to build a corporation; Not here to build Schools; I am not here to build churches—I am no Mother Theresa. What I will do, though, is—lead a legacy.”
– Dean Mathers